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. 2020 Dec 22;185(3):710–718. doi: 10.1002/ajmg.a.62024

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© 2020 The Authors. American Journal of Medical Genetics Part A published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Clinical characteristics of two probands with ANKRD11 variants. (a‐1) Proband 1 had a triangular face, large cheek bone, low bridge of the nose and normal teeth. (a‐2) X‐ray examination of proband 1 at the age of 8 years and 4 months showing a delayed bone age (6.83 years) (by the Greulich‐Pyle method). (a‐3) X‐ray examination of proband 1 at the age of 10 years and 8 months showing an advanced bone age (12 years) (by the Greulich‐Pyle method). (a‐4) Growth curves of proband 1 showed an unideal growth tendency. Green arrow: delayed bone age; Blue arrow: advanced bone age. (b‐1) X‐ray examination showed an advanced bone age of proband 2 (by the Greulich‐Pyle method). (b‐2) Growth curves of proband 2 showed an unideal growth tendency. Approximate growth tendency from 6 years old to 9 years old was indicated by dotted line. Blue arrow: advanced bone age [Color figure can be viewed at wileyonlinelibrary.com]