FIGURE 1.

Workflow of experimental design. First, somatic copy number alteration (SCNA) was examined using a Cytoscan HD. Second, messenger RNAs (mRNA) expression was investigated according to the following criteria: fold‐change in expression (<−1.5 or >1.5) and P < .05 using a Clariom S Human Array, compared with that of normal gland. Third, SCNAs with altered gene expression were pooled in adenoma, intramucosal cancers (IMC) and colorectal cancer (CRC). Finally, the association of selected mRNAs with corresponding gene expression was validated