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. 2020 Apr 19;117(3):743–755. doi: 10.1093/cvr/cvaa069

Figure 6.

Figure 6

TFR cell population is not able to repair established atherosclerosis lesions. (A) Mouse atherosclerosis protocols and adoptive transfer strategy. (B) Quantification of atherosclerotic lipid content and representative microphotographs of aortic root plaques (Oil Red O staining) in Apoe−/− mice treated with vehicle (PBS) or Bcl-6 inhibitor under NCD and HCD (n = 6 mice/group). Original magnification, ×10. Scale bars, 400 μm. (C) Quantification of atherosclerotic lipid content and representative microphotographs from Oil Red O-stained abdominal aortas (n = 6 mice/group). Scale bars, 500 μm. (D) Effect of TFR cell transfer on secondary lymphoid organs TFH and TFR populations on established atherosclerosis mice (n = 5–6 mice/group). (E) Effect of TFR cell transfer on secondary lymphoid organs in B cell populations on established atherosclerosis mice (n = 5–8 mice/group). The non-parametric Mann–Whitney U test was used for statistical analysis: *P ≤ 0.05. All data were represented as mean ± SEM.