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. 2020 Apr 6;117(3):792–804. doi: 10.1093/cvr/cvaa089

Figure 3.

Figure 3

Knockdown of RyR1/RyR2 suppressed STOCs in uterine arteries of pregnant sheep. Uterine arteries of pregnant animals were treated with scramble control siRNAs or siRNAs for RyR1, RyR2, and RyR3, respectively. STOCs were measured in uterine artery vascular smooth muscle cells 48 hours later. (A) Representative traces showing STOCs at holding potentials of 10 mV in uterine artery vascular smooth muscle cells. (B) STOC frequency. (C) STOC amplitude. Data are means ± SEM from five animals of each group; repeated measures ANOVA with the post hoc Bonferroni/Dunn test; *P < 0.05, RyR siRNAs vs. control siRNA.