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. 2020 Apr 6;117(3):792–804. doi: 10.1093/cvr/cvaa089

Figure 4.

Figure 4

Knockdown of RyR1/RyR2 increased myogenic tone in uterine arteries of pregnant sheep. Uterine arteries of pregnant animals were treated with scramble control siRNAs or siRNAs for RyR1, RyR2, and RyR3, respectively. Pressure-dependent myogenic tone was measured in uterine arteries 48 h later. (A–C) Changes of lumen diameters of uterine arteries in response to increases in intravascular pressure. (D) Data summary showing the percentage myogenic tone in RyR siRNA-treated uterine arteries. Data are means ± SEM from five animals of each group; repeated measures ANOVA with the post hoc Bonferroni/Dunn test; *P < 0.05, RyR siRNAs vs. untreated control or control siRNA.