Table 2.
The origin and distribution of SARS-CoV-2 clades based on Nextsrain clustering.
| Clade | Root clade/ | Main characteristics | Region |
|---|---|---|---|
| 19A | The root clade that | China then to the rest of Asia | |
| 19B, | The ancestor Wuhan strain (December 2019) | Wuhan strain | |
| 20A | 19A | Spike: D614G | Europe |
| 20B | 20A | Spike: D614G | Europe |
| 20C | 20A | Spike: D614G | North America |
| 20D, | 20B | ORF1a: 1246I and ORF1a 3278S | South America, Southern Europe, and South Africa |
| 20E | 20A | Spike: 222V, N: 220V, ORF10: 30L, and ORF14: 67F | Europe |
| 20F | 20B | ORF1a: 300F and Spike: 477N | Australia |
| 20G | 20C | ORF1b: 1653D, ORF3a: 172V, N 67S and N 199L, | United States |
| 20H/501Y.V2 | 20C | Spike: 80A, 215G, 484K, 501Y, and 701V | South Africa |
| 20I/501Y.V1 | 20B | Spike (501Y, 570D, 681H) ORF8(27*) | United Kingdom |