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. 2021 Feb 22;7(2):e06350. doi: 10.1016/j.heliyon.2021.e06350

Figure 1.

Figure 1

The schematics representing the potential mechanisms by which curcumin may be effective against COVID-19 (A) Antiviral activity of curcumin against SARS-CoV-2 mediated by disrupting the viral envelope, S protein and or ACE2, which prevents the entry of the virus into the cells. B. Curcumin induces antiviral responses by positively regulating NRF2 and repressing ACE2 expression by negatively regulating HMGB1. C. Curcumin mediates immunomodulatory responses by inhibiting cytokine response syndrome and oxidative stress and thus mitigating the progression to pneumonia and or ARDS following SARS-CoV-2 infection.