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. 2021 Feb 4;10:594182. doi: 10.3389/fonc.2020.594182

Table 2.

Feedback given to WFO and the corresponding updated status.

Feedback time Suggestion Updated time
2017.3 Apply adjuvant therapy to patient <80 y 2017.3
2017.5 Genetic analysis should be mandatory 2017.5
2017.5 Stage II: High-Risk Evaluation + MSI test should be added MSI (2017.9)
Risk Evaluation (2018.1)
2017.5 Add previous therapy details 2017.5
2017.4 NCCN/ESMO Guidelines should list as the top priority as well; classic publications recommended Updated every 3 months
2017.5 Indication for neoadjuvant therapy: CRM/EMVI evaluation 2017.9
2017.5 RFA should be considered as a candidate option for mCRC treatment IBM feedback pending
2017.8 Evaluation of pCR and NED should be added IBM feedback pending

MSI, Microsatellite instability; NCCN, National Comprehensive Cancer Network; ESMO, European Society for Medical Oncology; CRM, Circumferential resection margin; EMVI, Extramural vascular invasion; pCR, Pathological complete response; NED, No evidence of disease; RFA, Radio-frequency ablation; mCRC, Metastatic colorectal cancer.