Table 2.

Correlations between cardiorespiratory fitness and estrogen metabolism measures: Cross-sectional at baseline and longitudinal changes over time

	Cross-sectional at baselineb	Changes over timec
Estrogens, estrogen metabolites, and metabolic pathwaysa	R	R
Parent estrogens	−0.03	−0.05
Estrone	−0.02	−0.05
Estradiol	−0.08	−0.07
2-pathway	−0.15	−0.14
2-Hydroxyestrone	−0.18	−0.14
2-Hydroxyestradiol	−0.08	−0.10
2-Methoxyestrone	−0.04	−0.03
2-Methoxyestradiol	−0.06	−0.08
2-Hydroxyestrone-3 methyl ether	−0.03	−0.11
4-pathway	−0.08	−0.09
4-Hydroxyestrone	−0.13	−0.08
4-Methoxyestrone	−0.01	−0.08
4-Methoxyestradiol	0.03	−0.02
16-pathway	−0.03	−0.07
16α-hydroxyestrone	−0.07	−0.02
17-Epiestriol	−0.02	−0.07
Estriol	−0.01	−0.08
16-Ketoestradiol	−0.04	−0.04
16-Epiestriol	−0.07	−0.09
2-pathway/parent estrogens ratio	−0.10	−0.10

^aIncludes glucuronidated, sulfated, and unconjugated forms for each estrogen, estrogen metabolite, and metabolic pathway.

^bBased on linear regression of fitness on estrogen metabolism measures, adjusted for age, education, ethnicity, family history of breast cancer, energy intake, and BMI at baseline. Includes both exercise and control arms. Significant correlations are bolded.

^cBased on linear regression of fitness change scores between baseline and 12-months on changes in estrogen metabolism measures over the same time interval, adjusted for age, education, ethnicity, family history of breast cancer, energy intake, and weight change over time. Includes both exercise and control arms. Significant correlations (p< 0.05) are bolded.