Table 3.
% total neuronal population | % nociceptors (CGRP and/or P2X3R positive) | % other neurons (CGRP and/or P2X3R-negative) | Total # neurons assessed | |||||
---|---|---|---|---|---|---|---|---|
Target | Mouse | Human | Mouse | Human | Mouse | Human | Mouse | Human |
CD68 | non-neuronal | non-neuronal | non-neuronal | non-neuronal | non-neuronal | non-neuronal | ||
CALCA | 32.9 | 59.1 | 32.9 | 59.1 | 0 | 0 | 12714 | 5388 |
CHRNA6 | 30.3 | 43.8 | 27.7 | 34.4 | 2.6 | 9.40 | 1194 | 410 |
CHRNA9 | ND | 25.6 | ND | 25.3 | ND | 0.30 | 468 | |
CHRNA10 | 1.65 | 3.68 | 1.32 | 3.01 | 0.33 | 0.67 | 1682 | 366 |
CRLF2 | 70.4 | 4.57 | 52.1 | 3.83 | 18.3 | 0.74 | 1348 | 360 |
HCN1 | 70.9 | 94.4 | 43.4 | 73.9 | 27.5 | 20.5 | 1483 | 334 |
HCN2 | 71.5 | 44.0 | 44.2 | 24.9 | 27.3 | 19.1 | 1266 | 331 |
HDAC6 | 86.6 | 58.0 | 60.2 | 48.1 | 26.4 | 9.90 | 1344 | 326 |
KCNB1 | 85.4 | 65.2 | 20.2 | 605 | ||||
KCNS1 | 55.5 | 42.4 | 29.4 | 12.1 | 26.1 | 30.3 | 1176 | 368 |
P2RX3 | 66.3 | 52.6 | 66.3 | 52.6 | 0 | 0 | 12714 | 5388 |
SCN9A | 96.0 | 69.0 | 27.0 | 285 | ||||
SCN10A | 71.0 | 71.0 | 0 | 529 | ||||
TRPA1 | 55.2 | 16.3 | 53.6 | 16.0 | 1.60 | 0.30 | 1606 | 583 |
TRPV1 | 32.4 | 74.7 | 29.8 | 66.6 | 2.54 | 8.10 | 1438 | 423 |