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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Drug Alcohol Depend. 2021 Jan 10;220:108518. doi: 10.1016/j.drugalcdep.2021.108518

Figure 4:

Figure 4:

Hnrnph1+/− mice do not exhibit alcohol-induced place-aversion. Wild-type mice (+/+) and their littermates with a heterozygous deletion of Hnrnph1 (+/−) underwent an alcohol-induced place-conditioning procedure involving 8 pairings of alcohol (0.5–4 g/kg) with a distinct compartment of a 2-compartment apparatus. While female mice (A) locomoted more than males (B) in response to alcohol injection during the first conditioning session, no genotypic differences were detected in the shape of the dose-response function for acute alcohol-induced locomotion. (C) When allowed free-access to both compartments following conditioning, we detected no sex difference in alcohol-induced place-conditioning. Thus, the data were collapsed across sexes to illustrate the large genotypic difference in the direction of the conditioned response between +/+ (aversion) and +/− mice (preference). The data represent the means ± SEMs of the number of mice indicated in Panels A and B. *p < 0.05 vs. +/+; +p < 0.05 vs. unpaired side (place-conditioning)