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Overall balance of oxidant and antioxidant functions of Ahr balancing healthspan. Healthspan is potentially decreased with chronic elevation of Ahr activity and ROS accumulation. This may be partially attenuated by exercise, which can suppress Ahr expression in muscle and increase kynurenine aminotransferase expression. Small molecules such as metformin and resveratrol may also improve healthspan by decreasing Ahr expression and antagonizing Ahr activity.
