Table 2.

Characteristics of food allergic disorders emphasizing life course

Disorder	Age-related Features	Natural Course
IgE-mediated food allergies/anaphylaxis	Foods triggering the most severe reactions are similar across the life course (peanut, tree nuts, shrimp, fish) Severity is similar across the life course with 42% to 53% having severe reactions	More severe egg/milk allergies in adults are those carried over from childhood Egg, milk, wheat, soy allergies more likely to resolve than peanut, tree nuts, fish, shellfish allergies
Food Protein-induced allergic proctocolitis (FPIAP)	Characteristically a disease of infancy Some overlap features with adult eosinophilic colitis	Resolution during infancy
Food protein-induced enterocolitis (FPIES)	Typical onset in infancy from milk, soy, oat, rice with males >females Geographic variation in triggers Adult onset described in various cases/case series more often shellfish, fish and females > males	Typically resolves in infancy/early childhood
Eosinophilic esophagitis (EoE)	Infant and young children presenting symptoms characterized by reflux, poor growth Older child/adult presenting with heartburn, dysphagia, chest pain, impaction Increasing fibrosis noted on biopsy by age, reflecting years of ongoing inflammation	Persistent
Atopic dermatitis (AD)	Roughly 1/3 of children with moderate-severe AD experience food allergy (food allergy as a cause of chronic rash is less common) Limited data on contribution of food allergy to adult AD	Course associated with food allergy natural course
Pollen food allergy syndrome	Not described in infancy Common allergic disease in children and adults, possibly increase in prevalence with age	Likely persistent with variations in severity