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Vascular factors affecting cancer metastasis. a) Cancer cells intravasate into blood vessels near or in the tumor to enter the systemic circulation, where they then extravasate into secondary metastatic sites. b) The important factors of the vasculature and endothelium focused on in this review that affect intravasation, circulation, and extravasation are EC heterogeneity, hemodynamics, and the extracellular matrix.
