TABLE 1.
Demographic and Neuropathological Characteristics of Cases Evaluated by Braak Stage
| Braak I–II Entorhinal | Braak III–IV Limbic | Braak V–VI Neocortical | p Value | |
|---|---|---|---|---|
| n = 44 | n = 210 | n = 101 | ||
| Age at death (y) | 82.39 ± 5.84 | 89.04 ± 6.30 | 85.17 ± 7.50 | <0.001 |
| Sex Male/female (% male) | 31/13 (70%) | 92/118 (44%) | 55/46 (54%) | 0.003* |
| Education (y) | 15.36 ± 2.54 | 14.82 ± 2.53 | 14.50 ± 2.67 | 0.16 |
| Consensus diagnosis (CU/MCI/AD) | 37/3/4 | 145/26/39 | 1/2/98 | <0.001* |
| APOE ε4 Carrier/noncarrier (% carrier) | 8/35 (19%) | 41/167 (20%) | 56/44 (56%) | <0.001* |
| Postmortem interval (hours) | 2.94 (2.38, 3.50) | 2.91 (2.50, 3.50) | 3.00 (2.50, 3.50) | 0.92 |
| Brain weight at autopsy (g) | 1,236.61 ± 140.43 | 1,160.81 ± 108.77 | 1,079.40 ± 117.84 | <0.001 |
| Lewy body pathology (yes/no) | 10/34 | 59/151 | 58/43 | <0.001* |
| CERAD neuritic plaque density | <0.001* | |||
| None | 21 | 55 | 2 | |
| Sparse | 8 | 43 | 1 | |
| Moderate | 8 | 41 | 3 | |
| Frequent | 7 | 70 | 95 | |
| Circles of Willis atherosclerosis | 2.09 ± 1.64 | 1.96 ± 1.17 | 2.08 ± 1.15 | 0.56 |
| White matter rarefaction | 2.81 ± 2.80 | 3.66 ± 3.05 | 5.47 ± 3.40 | <0.001 |
| Microinfarct number | 0.02 ± 0.05 | 0.42 ± 1.95 | 0.54 ± 2.40 | 0.03 |
| Cerebral amyloid angiopathy | 1.57 ± 2.68 | 2.68 ± 3.29 | 5.69 ± 3.84 | <0.001 |
Mean ± SD; Median (interquartile range) for postmortem interval.
*
p value determined via Chi-square analysis. All others determined via Kruskal-Wallis analysis.