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. 2021 Feb 18;13:1673–1686. doi: 10.2147/CMAR.S295833

Figure 1.

Figure 1

Circ_0006174 was upregulated in CRC tissues and was associated with CRC progression. (A–C) Heat map of top 15 upregulated circRNAs in CRC tissues and adjacent normal tissues from GSE142837, GSE138589, and GSE126094 datasets. (D) Circ_0006174 forms a circular structure through exons 3 and exons 4 in RAD23B gene. (E) Relative expression of circ_0006174 in CRC tissues (n=40) and adjacent normal tissues (n=40) was detected by RT-qPCR. (F) RT-qPCR was employed to detect circ_0006174 expression in patients with stage I–II CRC tissues (n=28) or stage III CRC tissues (n=12). (G) RT-qPCR was used to analyze circ_0006174 expression in patients with negative lymph node metastasis tissues (n=23) or positive lymph node metastasis tissues (n=17). (H) Kaplan-Meier survival analysis with a Log rank test was performed to compare the overall survival rate of CRC patients with higher (High circ_0006174) or lower (Low circ_0006174) level than median circ_0006174 expression level. Experiments were performed in triplicate, and data were presented as means ± SD. *P<0.05.