Table 1. Demographic and clinical data for participants.
| Factor | MCI | AD | p-value | Adjusted p-value |
|---|---|---|---|---|
| Participants: N | 112 | 128 | ||
| Women: N (%) | 68 (60.7) | 89 (69.5) | 0.174 | 0.21 |
| Men: N (%) | 44 (39.3) | 39 (30.5) | ||
| Age: mean (SD) | 77.47 (6.11) | 78.28 (5.88) | 0.298 | 0.33 |
| Education year: mean (SD) | 10.88 (2.42) | 10.80 (2.62) | 0.791 | 0.791 |
| MMSE: mean (SD) | 25.93 (2.38) | 22.84 (2.05) | <0.001 | <0.05 |
| eZIS extent: mean (SD) | 11.78 (8.97) | 15.20 (10.30) | 0.007 | <0.05 |
| eZIS ratio: mean (SD) | 2.11 (1.53) | 2.47 (1.47) | 0.066 | 0.09 |
| eZIS severity: mean (SD) | 1.16 (0.31) | 1.29 (0.35) | 0.002 | <0.05 |
| VSRAD GM extent: mean (SD) | 3.69 (1.98) | 4.94 (2.74) | <0.001 | <0.05 |
| VSRAD VOI extent: mean (SD) | 14.19 (21.34) | 34.71 (30.68) | <0.001 | <0.05 |
| VSRAD ratio: mean (SD) | 3.55 (4.69) | 7.18 (6.53) | <0.001 | <0.05 |
| VSRAD VOI severity: mean (SD) | 1.16 (0.79) | 1.88 (1.07) | <0.001 | <0.05 |
Abbreviations in Table 1: mild cognitive impairment, MCI; Alzheimer’s disease, AD; Voxel-based Specific Regional Analysis System for Alzheimer’s Disease, VSRAD; volume of interest, VOI; gray matter atrophy in the whole brain, GM; easy Z-score imaging system, eZIS; standard deviation, SD.
An adjusted p-value <0.05 was regarded as significant using the Benjamini-Hochberg procedure due to multiple testing.