Fig 1. Dietary palmitate induces cartilage lesion and synovial hyperplasia in a mouse OA model.

Mice were fed with a control, palmitate, or oleate diet (n = 15 per diet group) for 20 weeks. (A) Body weights of mice were measured at weeks 0, 10, and 20, respectively. Values are mean ± standard deviation. Mouse knee joints were then collected, processed and sectioned (one section from one knee per mouse) for histological analyses including (B) ACS score on medial tibial plateau, (C) viable chondrocyte counts per cartilage area, and (D) synovial hyperplasia score, with (E) hematoxylin and eosin (H&E) staining of mouse knee joint sections showing viable chondrocytes with blue-stained nuclei. Black arrow represents fibrillation of the articular cartilage. Scale bar, 50 μm.