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. 2021 Feb 22;15(2):e0009103. doi: 10.1371/journal.pntd.0009103

Table 3. Rank classification of clinical symptoms and laboratory findings on admission.

Clinical symptoms and laboratory findings Number of patients evaluated Rank Overall Groups p-Value*
Fatal Non-fatal
Body temperature 23 1 8 (34.8%) 1/4 (25.0%) 7/19 (36.8%) 0.66
2 8 (34.8%) 1/4 (25.0%) 7/19 (36.8%)
3 5 (21.7%) 1/4 (25.0%) 4/19 (21.1%)
4 2 (8.7%) 1/4 (25.0%) 1/19 (5.3%)
Headache 19 1 13 (68.4%) 1/3 (33.3%) 12/16 (75.0%) 0.09
2 5 (26.3%) 1/3 (33.3%) 4/16 (25.0%)
3 1 (5.3%) 1/3 (33.3%) 0/16 (0%)
4 0 (0%) 0/3 (0%) 0/16 (0%)
Body aches and pains 18 1 12 (66.7%) 2/3 (66.7%) 10/15 (66.7%) 1.00
2 2 (11.1%) 0/3 (0%) 2/15 (13.3%)
3 4 (22.2%) 1/3 (33.3%) 3/15 (20.0%)
4 0 (0%) 0/3 (0%) 0/15 (0%)
Vomiting 21 1 17 (81.0%) 4/4 (100%) 13/17 (76.5%) 0.55
2 4 (19.0%) 0/4 (0%) 4/17 (23.5%)
3 0 (0%) 0/4 (0%) 0/17 (0%)
4 0 (0%) 0/4 (0%) 0/17 (0%)
Abdominal pain 18 1 12 (66.7%) 1/3 (33.3%) 11/15 (73.3%) 0.10
2 5 (27.8%) 1/3 (33.3%) 4/15 (26.7%)
3 1 (5.6%) 1/3 (33.3%) 0/15 (0%)
4 0 (0%) 0/3 (0%) 0/15 (0%)
Diarrhea 20 1 10 (50.0%) 0/3 (0%) 10/17 (58.8%) 0.03
2 7 (35.0%) 1/3 (33.3%) 6/17 (35.3%)
3 2 (10.0%) 1/3 (33.3%) 1/17 (5.9%)
4 1 (5.0%) 1/3 (33.3%) 0/17 (0%)
Dyspnea 18 1 13 (72.2%) 2/2 (100%) 11/16 (68.8%) 1.00
2 4 (22.2%) 0/2 (0%) 4/16 (25.0%)
3 1 (5.6%) 0/2 (0%) 1/16 (6.3%)
4 0 (0%) 0/2 (0%) 0/16 (0%)
Hemorrhage 22 1 18 (81.8%) 4/4 (100%) 14/18 (77.8%) 1.00
2 1 (4.5%) 0/4 (0%) 1/18 (5.6%)
3 1 (4.5%) 0/4 (0%) 1/18 (5.6%)
4 2 (9.1%) 0/4 (0%) 2/18 (11.1%)
Disorientation 21 1 9 (42.9%) 1/4 (25.0%) 8/17 (47.1%) 0.53
2 9 (42.9%) 2/4 (50.0%) 7/17 (41.2%)
3 2 (9.5%) 1/4 (25.0%) 1/17 (5.9%)
4 1 (4.8%) 0/4 (0%) 1/17 (5.9%)
WBC 23 1 2 (8.7%) 0/4 (0%) 2/19 (10.5%) 0.21
2 9 (39.1%) 0/4 (0%) 9/19 (47.4%)
3 10 (43.5%) 3/4 (75.0%) 7/19 (36.8%)
4 2 (8.7%) 1/4 (25.0%) 1/19 (5.3%)
Plt 23 1 0 (0%) 0/4 (0%) 0/19 (0%) 0.66
2 1 (4.3%) 0/4 (0%) 1/19 (5.3%)
3 12 (52.2%) 3/4 (75.0%) 9/19 (47.4%)
4 10 (43.5%) 1/4 (25.0%) 9/19 (47.4%)
AST 23 1 0 (0%) 0 /4 (0%) 0/19 (0%) 0.69
2 4 (17.4%) 0/4 (0%) 4/19 (21.1%)
3 2 (8.7%) 0/4 (0%) 2/19 (10.5%)
4 17 (73.9%) 4/4 (100%) 13/19 (68.4%)
ALT 23 1 4 (17.4%) 0/4 (0%) 4/19 (21.1%) 0.09
2 8 (34.8%) 0/4 (0%) 8/19 (42.1%)
3 5 (21.7%) 2/4 (50.0%) 3/19 (15.8%)
4 6 (26.1%) 2/4 (50.0%) 4/19 (21.1%)
LDH 23 1 0 (0%) 0/4 (0%) 0/19 (0%) 0.02
2 8 (34.8%) 0/4 (0%) 8/19 (42.1%)
3 9 (39.1%) 4/4 (100%) 5/19 (26.3%)
4 6 (26.1%) 0/4 (0%) 6/19 (31.6%)
CK 23 1 3 (13.0%) 0/4 (0%) 3/19 (15.8%) 1.00
2 3 (13.0%) 1/4 (25.0%) 2/19 (10.5%)
3 6 (26.1%) 1/4 (25.0%) 5/19 (26.3%)
4 11 (47.8%) 2/4 (50.0%) 9/19 (47.4%)
Viral load 23 1 0 (0%) 0/4 (0%) 0/19 (0%) 0.053
2 5 (23%) 0/4 (0%) 5/19 (26.3%)
3 13 (56.5%) 1/4 (25.0%) 12/19 (63.2%)
4 5 (21.7%) 3/4 (75.0%) 2/19 (10.5%)

* Fisher’s exact test.

WBC = white blood cell count, Plt = platelet count, AST = aspartate transaminase, ALT = alanine transaminase, LDH = lactate dehydrogenase, CK = creatine kinase