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[Preprint]. 2021 Feb 16:2021.02.15.431215. [Version 1] doi: 10.1101/2021.02.15.431215

Fig. 6. Immune profile relationships between convalescent HIV positive and negative individuals.

Fig. 6.

(A) viSNE analysis of CD3 T cells in HIV negative (top panel) and HIV positive donors (lower panel). Each point on the high-dimensional mapping represents an individual cell and colour intensity represents expression of selected markers. (B) Frequency of CD4 and CD8 T cells out of total lymphocytes in SARS-CoV-2 convalescent HIV negative (HIV−, n=26) and HIV positive individuals (HIV+, n=19) via traditional gating. (C) Summary data of the proportion of CD45RA−/CCR7+ central memory (CM), CD45RA+/CCR7+ naïve, CD45RA+/CCR7− terminally differentiated effector memory (TEMRA) and CD45RA−/CCR7− effector memory (EM) CD4 and CD8 T cell subsets it the study groups. (D) Correlation between CD4:CD8 ratio and frequency of naïve CD4 T cells in HIV-positive individuals. (E) Correlation between frequency of naïve CD4 T cells and total SARS-CoV-2 T cell responses, detected via ELISpot, in HIV positive individuals. (F) Correlation between frequency of naïve CD4 T cells and (G) naïve CD8 T cells and age in HIV negative individuals. (H) Correlation between frequency of naïve CD4 T cells and (I) naïve CD8 T cells age in HIV positive donors. Significance determined by Mann-Whitney test, *p<0.05, **p<0.01, ***p < 0.001. The non-parametric Spearman test was used for correlation analysis.