Table 1:

Summary of TWAS and colocalization analyses in tissues and cell lines.

Gene symbol	Tissue	Discovery: GWASHGI				Validation: GWASSCGG
		TWAS z	TWAS p	PP	colocalized SNP p	TWAS z	TWAS p	PP	colocalized SNP p
CXCR6	Lung	−8.53	1.57×10−17	0.79*	rs34068335 5.02×10−22	−4.19	2.84×10−5	ns	-
	T follicular helper cells	-	-	0.99**	rs35081325 3.82×10−39	-	-	0.99**	rs35081325 2.49×10−10
CCR9	Whole blood	6.50	7.90×10−11	ns	-	6.26	3.78×10−10	ns	-

GWAS_HGI denotes the GWAS dataset from the Host Genetics Initiative.

GWAS_SCGG represents the GWAS dataset from the Severe COVID-19 GWAS Group.

PP: posterior probability.

z: z score.

p: p-value.

^*:statistically significant by the colocalization posterior probability (CLPP) from eCAVIAR.

^**:statistically significant by the regional colocalization probability (RCP) from fastENLOC.

ns: no significant colocalization from either eCAVIAR or fastENLOC.

^-:no available data.