Table 4.
Multivariate Cox Regression Analysis on the Risk Factors Associated with Mortality in Patients With COVID-19 from symptom onset
| Factors | Univariate analysis | Cox regression model | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Age, > 65 years | 3.79 (2.32–6.20) | < 0.001 | 2.01 (1.03–3.92) | 0.04 |
| Sex | 0.53 (0.34–0.82) | 0.005 | ||
| Hypertension | 2.05 (1.34–3.13) | 0.001 | ||
| COPD | 2.95 (1.64–5.32) | < 0.001 | ||
| Chronic heart disease | 2.16 (1.34–3.47) | 0.002 | ||
| Cerebrovascular disease | 3.10 (1.72–5.59) | < 0.001 | ||
| Myocardial injury | 7.02 (4.45–11.08) | < 0.001 | 4.55 (2.49–8.31) | < 0.001 |
| CRP | 1.01 (1.01–1.02) | < 0.001 | 1.01 (1.00–1.01) | 0.001 |
| NT-proBNP on admission | 1.00 (1.00–1.00) | 0.082 | ||
| PCT | 1.00 (1.00–1.02) | 0.768 | ||
| D-dimer | 1.01 (1.00–1.01) | 0.003 | ||
| NCP types | < 0.001 | 0.007 | ||
| severe-common | 3.89 (1.95–7.76) | < 0.001 | 2.18 (0.92–5.15) | 0.075 |
| critically severe-common | 18.42 (9.06–37.41) | < 0.001 | 4.33 (1.65–11.36) | < 0.001 |
P-values by Cox regression analyses. PCT, CRP, and NT-proBNP on admission, D-dimer were performed as continuous variables. NT-proBNP, N-terminal pro-B-type natriuretic peptide; COPD: chronic obstructive pulmonary disease; PCT, Procalcitonin; NCP: novel coronary pneumonia.