Table 3.
Case data for comorbid conditions.
| Case | Clinically Diagnosed Conditions | Autopsy Diagnosed Brain Conditions |
|---|---|---|
| B1 | CAD; Cig; COPD; Dem; DM; DL; HT; Ob | AD; VaD; HS; PSP; LATE |
| B2 | Afib; Cig; Dem; HT; PE | PD; AD; ARTAG; DBS |
| B3 | AA; CAD; Cig; COPD; DM; DL; Emphy; Gallst; HT; Ob; PVD; Steat | PART |
| B4 | AA; CAD; CarD; Cig; COPD; DL; Emphy; HT; Ob; PE; PVD; SLap | PART |
| B5 | CAD; Cig; CKD; DM; DL; Emphy; HT; Park; PF | AD; CWMR |
| B6 | CAD; CKD; DL; HT; Ob; Pace; Dem; Park | AD; PSP; TLBD; CWMR; LATE |
| B7 | Afib; Asth; CAD; CHF; CarD; HT; Ob; Pace; SLap; | PART |
| B8 | CAD; Cig; DL; MI | AD; MSA; LATE |
| B9 | DL; DM; Gallst; Ob; SLap; Steat | PART |
| B10 | Cig; Cirrh; DM; Emphy; Gallst; HT | Brain: PART |
| B11 | Afib; CAD; HT; DL; MI; Str, CKD; Cig | N/A |
| B12 | Afib; DL; CLL; CKD; Cig; Ob | N/A |
| B13 | HT; DL; DM; CAD; CKD; COPD; PVD; CRF; Ob | N/A |
| B14 | Afib; HT; PVD; COPD; PE; Str; Cig | N/A |
| M1 | Dem | AD; TLBD; VaD; Leuko; Crib; LATE |
| M2 | Dem | AD; ASCVD; Leuko; Crib |
| M3 | Dem | DLBD; AD |
| M4 | Park | PSP atypical (PNLA); TSA |
| M5 | Dem; Park | PSP; SC; ASCVD; Leuko; Crib |
| M6 | Dem | AD |
| M7 | Dem; Park | FTLD-TDP; VaD; Leuko; SC |
| M8 | Dem; Park | VaD; AD |
| M9 | Dem; Park | PSP (PNLA); PART; ARTAG |
| M10 | N/A | None |
| M11 | N/A | DLB |
Abbreviations for clinically-diagnosed conditions: Afib = atrial fibrillation; AA = aortic aneurysm; CarD = carotid artery disease; CAD = coronary artery disease; CHF = congestive heart failure; Cig = history of cigarette smoking; Cirrh = hepatic cirrhosis; CKD = chronic kidney disease; CLL = chronic lymphocytic leukemia; COPD = chronic obstructive pulmonary disease; Dem = dementia; DM = diabetes mellitus; DL = dyslipidemia; Emphy = emphysema; Gallst = gallstones; HT = hypertension; MI = myocardial infarction; Ob = obesity; Pace = cardiac pacemaker; Park = parkinsonism; PE = pulmonary embolism; PF = pulmonary fibrosis; PVD = peripheral vascular disease; SLap = sleep apnea; Steat = hepatic steatosis; Str = stroke. Abbreviations for autopsy-diagnosed conditions: AD = Alzheimer’s disease dementia; ARTAG = age-related tau astrogliopathy; ASCVD = atherosclerotic cerebrovascular disease; Crib = Cribriform state; CWMR = cerebral white matter rarefaction; DBS = deep brain stimulator; DLBD = diffuse Lewy body disease; FTLD-TDP = frontotemporal lobar degeneration with TDP-43 proteinopathy; HS = hippocampal sclerosis; Leuko = leukoencephalopathy; LATE = Limbic age-related TDP-43 encephalopathy; MSA = multiple system atrophy; PD = Parkinson’s disease; PART = primary age-related tauopathy; PNLA = pallido-nigro-luysian atrophy; PSP = progressive supranuclear palsy; SC = senile changes (less-than diagnostic plaque and tangle densities) ; TLBD = transitional Lewy body disease; VaD = vascular dementia. N/A = not available.