Extended data Fig 2. Neutralization by first dose BNT162b2 vaccine and convalescent sera against wild type and mutant (N501Y, A570D, ΔH69/V70) SARS-CoV-2 pseudotyped viruses:

(a-b) Vaccine sera dilution for 50% neutralization against WT and Spike mutant with N501Y, A570D, ΔH69/V70. Geometric mean titre (GMT) + s.d of two independent experiments with two technical repeats presented. (c-d) Convalescent sera dilution for 50% neutralization against WT and Spike mutant with N501Y, A570D, ΔH69/V70. GMT + s.d of representative experiment with two technical repeats presented. e, Representative curves of convalescent serum log₁₀ inverse dilution against % neutralization for WT v N501Y, A570D, ΔH69/V70. Where a curve is shifted to the right this indicates the virus is less sensitive to the neutralizing antibodies in the serum. Data are means of technical replicates and error bars represent standard error of the mean. Data are representative of 2 independent experiments. Limit of detection for 50% neutralization set at 10.