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. 2020 May 5;43(11):zsaa087. doi: 10.1093/sleep/zsaa087

Figure 2.

Figure 2.

Diurnal activity levels in wild-type (WT) and J20 mice in response to fenobam. Activity counts were assessed in 8-month-old WT and J20 mice after chronic treatment with vehicle or fenobam. Total activity counts (binned in 1 min increments) were averaged over 3–4 days of readings for cohorts and plotted on the y-axis versus a 24-h time period (in minutes). Time zero is “Lights On.” Cohorts consist of WT mice treated with vehicle (n = 7), J20 treated with vehicle (n = 7), WT treated with fenobam (n = 8), and J20 treated with fenobam (n = 6). (A) vehicle-treated WT (blue) versus J20 (orange). (B) WT mice treated with vehicle (blue) versus fenobam (red). (C) J20 mice treated with vehicle (orange) versus fenobam (green). Mice for these cohorts were tested in fall and winter.