Table 1.

Mouse Cohorts for Actigraphy Experiments

Experiment	WT			J20			t-test (p)
	N	Age (days)	Peak acrophase (min)	N	Age (days)	Peak acrophase (min)
A: fall	15	231 ± 8	836 ± 82	13	232 ± 8	1,081 ± 143	<0.000006
B: winter	20	248 ± 13	941 ± 142	19	244 ± 13	1,041 ± 121	<0.01
C: spring	12	260 ± 5	859 ± 117	8	259 ± 7	1,096 ± 104	<0.0003

Three cohorts of wild-type (WT) and J20 littermate mice were tested by actigraphy during various seasons (set A: fall, set B: winter, set C: spring). A minimum of eight mice were tested per cohort. Average age of the mice was 8 months old (presented in days ± SD). Average peak acrophase is the peak activity time in minutes from Zeitgeber time zero ± SD. Two-way ANOVA based on season and genotype: interaction F(2,81) = 3.56, p = 0.033; season F(2,81) = 0.57, p = 0.57; genotype, F(1,81) = 49.8, p < 0.0001. One-way ANOVA for WT cohorts as a function of season F(2,44) = 3.73, p = 0.032. One-way ANOVA for J20 cohorts as a function of season: F(2,37) = 0.68, p = 0.51. Post hoc t-tests for WT: fall versus winter p = 0.015, fall versus spring p = 0.55, winter versus spring p = 0.10.