Table 1.
Multivariable analysis for overall survival
| Clinical variables | Patient characteristics |
Percent (n) (n = 431) |
Multivariable analysis | |||
| 2-year OS (%) | HR | 95% CI | p value | |||
| Age | < 40 years | 76 (326) | 81 | Ref | ||
| ≥ 40 years | 24 (105) | 54 | 1.3 | 0.8 to 1.8 | 0.29 | |
| Gender | Male | 58 (251) | Not included | |||
| Female | 42 (180) | Not included | ||||
| Local control | Limb salvage | 64 (276) | 83 | Ref | ||
| Amputation | 26 (113) | 74 | 1.6 | 1.1 to 2.3 | 0.008 | |
| Palliative | 10 (42) | 17 | 2.9 | 1.6 to 5.2 | < 0.001 | |
| Subtype | Primary | 92 (398) | 78 | Ref | ||
| Secondary | 8 (33) | 35 | 1.8 | 1.0 to 3.2 | 0.03 | |
| Tumor size | 0 to 7.9 cm | 24 (105) | 80 | Ref | ||
| ≥ 8.0 cm | 75 (322) | 73 | 1.6 | 1.0 to 2.3 | 0.03 | |
| Pathological fracture | No | 84 (361) | Not included | |||
| Yes | 16 (70) | Not included | ||||
| Tumor site | Extremity | 86 (371) | 80 | Ref | ||
| Axial | 14 (60) | 43 | 0.9 | 0.6 to 1.6 | 0.88 | |
| Chemotherapy-induced necrosis | < 90% | 42 (180) | 76 | Ref | ||
| ≥ 90% | 34 (146) | 94 | 0.4 | 0.3 to 0.6 | < 0.001 | |
| Stage | No metastases | 70 (302) | 83 | Ref | ||
| IPN | 16 (68) | 65 | 1.9 | 1.3 to 2.8 | 0.001 | |
| Metastases | 14 (61) | 45 | 3.0 | 2.0 to 4.4 | < 0.001 | |
OS = overall survival; HR = hazard ratio; Ref = the reference variable for multivariable analysis.