Table 2.
Multivariable analysis for metastasis-free survival
| Clinical variables | Patient characteristics | Percent (n) (n = 370) |
2-year MFS (%) | Multivariable analysis | |||
| HR | 95% CI | p value | |||||
| Age | < 40 years | 76 (281) | Not included | ||||
| ≥ 40 years | 24 (89) | Not included | |||||
| Gender | Male | 58 (215) | Not included | ||||
| Female | 42 (155) | Not included | |||||
| Local control | Limb salvage | 68 (251) | 74 | Ref | |||
| Amputation | 26 (95) | 59 | 1.5 | 1.1 to 2.2 | 0.02 | ||
| Palliative | 6 (24) | 52 | 0.9 | 0.4 to 2.0 | 0.85 | ||
| Subtype | Primary | 92 (342) | Not included | ||||
| Secondary | 8 (28) | Not included | |||||
| Tumor size | 0 cm to 7.9 cm | 27 (99) | Not included | ||||
| ≥ 8.0 cm | 73 (271) | Not included | |||||
| Pathological fracture | No | 84 (309) | Not included | ||||
| Yes | 16 (61) | Not included | |||||
| Tumor site | Extremity | 86 (320) | Not included | ||||
| Axial | 14 (50) | Not included | |||||
| Chemotherapy-induced necrosis | < 90% | 43 (160) | 63 | Ref | |||
| ≥ 90% | 35 (129) | 83 | 0.6 | 0.4 to 0.8 | 0.005 | ||
| Stage | No metastases | 82 (302) | 77 | Ref | |||
| IPN | 18 (68) | 35 | 3.6 | 2.5 to 5.2 | < 0.001 | ||
MFS = metastasis-free survival; Ref = the reference variable for multivariable analysis.