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(A) Immunohistochemical staining of OPN in the tissues of HCC patients. Scale bar; 50 μm. (B) Double immunofluorescence was carried out in HCC tissues. OPN expression in the cells was indicated in green, αSMA positivity was indicated in red, and OPN plus αSMA positivity was indicated in yellow. Scale bar; 50 μm, scale bar of large image; 25 μm. (C) The proposed model of cancer-TAM-CAF interactions via OPN.
