Figure 4.
Genomic distribution of Neu5Ac utilizers and degraders in human gut microbiome strains. The phylogenetic tree was constructed using concatenated sequences of universal ribosomal proteins from approximately 2,600 human gut microbial genomes from the PATRIC genomic database107 by RAxML version 8,108 then shrunk to genus representatives and visualized via iTOL.109 Numbers next to genera in the outermost level of the tree indicate the number of analyzed genomes per genus. Bars adjacent to each genus indicate the proportion of genomes that contain genes for: a Neu5Ac transporter and full Neu5Ac catabolism pathway (gold bars); and one or more Neu5Ac sialidase genes (purple bars). Genera mentioned in this review are shown in red text