Table 1. Summary of peak current ratios and ΔΔGDZ for mutations in the L9'T background.
Data are mean ± standard deviation (# oocytes), and individual data points are shown in Figures 3B, 5B, 6C, and 7C.
| IPTX /IGABA-max | IDZ-max /IPTX | ΔΔGDZ (kcal/mol) | |
|---|---|---|---|
| L9'T | 0.36 ± 0.04 (5) | 1.35 ± 0.05 (5) | −0.31 ± 0.04 (5) |
| L9'T/L276A | 0.22 ± 0.09 (4) | 1.62 ± 0.07 (5) | −0.45 ± 0.04 (5) |
| L9'T/P277A | 0.45 ± 0.03 (3) | 1.41 ± 0.17 (5) | −0.46 ± 0.20 (5) |
| L9'T/K278A | 0.20 ± 0.06 (5) | 1.67 ± 0.15 (4) | −0.44 ± 0.08 (4) |
| L9'T/V279A | 0.17 ± 0.04 (4) | 3.30 ± 0.70 (5) | −1.11 ± 0.30 (5) |
| L9'T/V279D | 0.02 ± 0.005 (3) | 2.31 ± 0.08 (3) | −0.52 ± 0.02 (3) |
| L9'T/V279W | 0.16 ± 0.05 (2) | 1.96 ± 0.23 (3) | −0.53 ± 0.10 (3) |
| L9'T/Y281A | 0.25 ± 0.07 (5) | 1.59 ± 0.11 (4) | −0.42 ± 0.07 (4) |
| L9'T/T283A | 0.11 ± 0.03 (5) | 1.71 ± 0.10 (6) | −0.38 ± 0.04 (6) |