Table 4.

Incidence rate ratios of otitis media/acute otitis media diagnoses between vaccine cohorts adjusted for confounding variables, according to the age-period-cohort Poisson model

	Skåne			VGR
PCV Cohorts	IRR	95% CI	p-value	IRR	95% CI	p-value
≤5 years of age
PHiD-CV/PCV13 relative to pre-PCV	0.901	0.849; 0.956	<0.001	0.977	0.924; 1.032	0.401
PHiD-CV/PCV13 relative to PCV7	0.926	0.884; 0.970	0.001	1.017	0.969; 1.067	0.493
PCV7 relative to pre-PCV	0.973	0.932; 1.015	0.207	0.961	0.917; 1.006	0.087
≤2 years of age
PHiD-CV/PCV13 relative to pre-PCV	0.952	0.866; 1.047	0.310	0.952	0.874; 1.037	0.263
PHiD-CV/PCV13 relative to PCV7	0.967	0.904; 1.035	0.330	0.994	0.930; 1.063	0.871
PCV7 relative to pre-PCV	0.985	0.927; 1.046	0.614	0.958	0.901; 1.018	0.164

CI = confidence interval, IRR = incidence rate ratio, PCV = pneumococcal conjugate vaccine, PCV7/PCV13 = 7-valent/13-valent pneumococcal conjugate vaccine, PHiD-CV = pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine, VGR = Västra Götalandsregionen