Table 2.
Clinical outcomes
| Pre-AOC implementation | Post-AOC implementation | P value* | |
|---|---|---|---|
| Died, n (%) | 30 (10.2) | 32 (10.8) | 0.81 |
| Culture proven sepsis, n (%) | 96 (32.8) | 121 (41.0) | 0.038 |
| Necrotising enterocolitis (> stage 2A), n (%) | 25 (8.5) | 27 (9.2) | 0.79 |
| Retinopathy of prematurity | |||
| none, (%) | 225 (90.0) | 226 (90.0) | 0.14 |
| ETROP 1 (treatment indication), n (%) | 16 (6.4) | 22 (8.8) | |
| ETROP 2 (watchful waiting indication), n (%) | 9 (3.6) | 3 (1.2) | |
| Received laser coagulation, n (%) | 13 (5.2) | 14 (5.6) | 0.84 |
| Intraventricular haemorrhage (≥ stage 2), n (%) | 55 (18.8) | 50 (16.9) | 0.56 |
| Periventricular leukomalacia (≥ stage 2), n (%) | 4 (1.4) | 6 (2.0) | 0.75 |
| Days in NICU, mean (SD) | 32.1 (25.6) | 35.1 (27.2) | 0.18 |
| Bronchopulmonary dysplasia | |||
| Severe, n (%) | 36 (14.0) | 48 (18.6) | 0.10 |
| Moderate, n (%) | 12 (4.7) | 4 (1.6) | |
| Mild, n (%) | 45 (17.4) | 38 (14.7) | |
Necrotising enterocolitis according to modified Bell staging criteria; ETROP, early treatment of retinopathy of prematurity; Intraventricular haemorrhage according to Papile’s classification; Days on NICU until transfer to peripheral hospital or discharge; Bronchopulmonary dysplasia classification according to Dutch paediatric guidelines.
*Statistical analysis with independent T-test, χ2, Fisher’s exact, or nonparametric Mann-Whitney U test as appropriate