Table 3.
Univariate and multivariate Cox regression analysis of the 10 miRNAs in patients with ESCC.
| Univariate analysis | Multivariate analysis | ||||
| Dataset | miRNA | HR (95% CI) | p value | HR (95% CI) | P value |
| TCGA-ESCA, ESCC | hsa-let-7d-5p | 2.24 (1.04–4.82) | .040∗ | 2.56 (1.05–6.24) | .039∗ |
| hsa-miR-105-5p | 0.85 (0.74–0.98) | .025∗ | 0.82 (0.69–0.97) | .022∗ | |
| hsa-miR-126-3p | 3.01 (1.56–5.78) | .001∗ | 3.04 (1.42–6.54) | .004∗ | |
| hsa-miR-192-5p | 1.84 (1.07–3.17) | .028∗ | 2.28 (1.14–4.54) | .019∗ | |
| hsa-miR-200b-3p | 0.73 (0.56–0.97) | .028∗ | 0.68 (0.52–0.91) | .008∗ | |
| hsa-miR-320a | 0.43 (0.22–0.86) | .017∗ | 0.36 (0.16–0.81) | .013∗ | |
| hsa-miR-340-3p | 2.36 (1.12–4.99) | .024∗ | 3.11 (1.28–7.51) | .012∗ | |
| hsa-miR-376b-3p | 0.51 (0.28–0.91) | .023∗ | 0.48 (0.24–0.96) | .038∗ | |
| hsa-miR-429 | 0.72 (0.54–0.96) | .023∗ | 0.67 (0.50–0.89) | .006∗ | |
| hsa-miR-494-3p | 0.52 (0.30–0.90) | .019∗ | 0.47 (0.25–0.89) | .020∗ | |
| GSE13937, ESCC | hsa-let-7d-5p | 2.26 (1.11–4.62) | .025∗ | 2.65 (1.06–6.65) | .038∗ |
| hsa-miR-105-5p | 1.8 (0.71–4.55) | .214 | 1.38 (0.49–3.86) | .543 | |
| hsa-miR-126-3p | 1.42 (0.81–2.5) | .222 | 1.63 (0.79–3.33) | .184 | |
| hsa-miR-192-5p | 1.74 (0.71–4.26) | .228 | 1.42 (0.53–3.81) | .482 | |
| hsa-miR-200b-3p | 1.27 (0.85–1.89) | .238 | 1.5 (0.88–2.54) | .135 | |
| hsa-miR-320a | 3.06 (1.25–7.53) | .015∗ | 2.37 (0.86–6.51) | .094 | |
| hsa-miR-340-3p | 1.13 (0.7–1.83) | .621 | 0.94 (0.56–1.57) | .815 | |
| hsa-miR-376b-3p | 1.59 (0.79–3.21) | .196 | 1.84 (0.83–4.07) | .130 | |
| hsa-miR-429 | 2.24 (0.87–5.74) | .094 | 1.74 (0.57–5.3) | .331 | |
| hsa-miR-494-3p | 1.01 (0.72–1.42) | .939 | 0.92 (0.61–1.38) | .675 | |
| GSE13937, ESCC adjacent tissue | hsa-let-7d-5p | 0.69 (0.28–1.74) | .432 | 0.98 (0.33–2.9) | .972 |
| hsa-miR-105-5p | 1.66 (0.85–3.24) | .139 | 1.51 (0.68–3.35) | .314 | |
| hsa-miR-126-3p | 0.94 (0.47–1.88) | .863 | 1.12 (0.45–2.78) | .803 | |
| hsa-miR-192-5p | 0.94 (0.63–1.4) | .761 | 0.9 (0.58–1.41) | .648 | |
| hsa-miR-200b-3p | 0.87 (0.6–1.24) | .435 | 0.69 (0.42–1.14) | .148 | |
| hsa-miR-320a | 2.24 (0.82–6.14) | .115 | 1.45 (0.52–4.01) | .474 | |
| hsa-miR-340-3p | 1.69 (0.92–3.12) | .091 | 1.47 (0.82–2.64) | .201 | |
| hsa-miR-376b-3p | 1.31 (0.71–2.42) | .390 | 1.52 (0.75–3.08) | .246 | |
| hsa-miR-429 | 1.57 (0.65–3.77) | .315 | 1.49 (0.57–3.91) | .417 | |
| hsa-miR-494-3p | 0.98 (0.66–1.44) | .903 | 0.82 (0.56–1.22) | .336 | |