TABLE 1.

Pharmacokinetic parameter values obtained from a noncompartmental analysis of 14 pregnant sheep after intravenous injection of 10 µg/kg of buprenorphine

Parameter	Description	Unit	Parameter value
AUCinf	Area under the curve from 0 h to infinity	h*µg/L	2.89 (1.72–40.2)
AUC%Extrap	Percent of extrapolated AUC from AUCinf	%	4.81 (1.47–27.5)
Cmax	Maximum plasma concentration	µg/L	4.31 (1.93–15.5)
CL	Plasma clearance	L/h/kg	3.39 (0.25–6.02) a
t½	Terminal half‐life	h	1.75 (1.07–31.0)
kel	Terminal rate constant	1/h	0.39 (0.022–0.65)
Vz	Apparent volume of distribution at the terminal phase	L/kg	9.89 (2.91–106.0) b
Vss	Apparent volume of distribution at steady‐state	L/kg	8.04 (1.05–49.3)

Data are presented as buprenorphine‐free base median (min−max).

^aMean CL 3.40 h*µg/L.

^bMean V_z 30.22 L/kg.