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. 2021 Feb 9;13:605970. doi: 10.3389/fnagi.2021.605970

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Copyright © 2021 Zhang, Shao, Xu, Liu, Liu, Luo, Jin and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of the least absolute shrinkage and selection operator (LASSO) model in PD patients. (A) The relationship between cross-validated mean square error and model size. Partial likelihood deviance is plotted against log (λ), where λ is the tuning parameter. Dotted vertical lines were drawn at the optimal values by minimum criteria and 1-s.e. criteria, and we selected 1-s.e. criteria to construct the model. (B) The distribution of the LASSO model in the testing cohort. (C) ROC curve of LASSO model for differentiating PDs from HCs of the testing cohort.