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. 2021 Feb 9;12:610859. doi: 10.3389/fmicb.2021.610859

FIGURE 7.

FIGURE 7

Azan-7 enhances the susceptibility to clindamycin in planktonic cultures of MRSA. (A) Determination of clindamycin MIC50 on planktonic MRSA cultures (n = 3). (B) Planktonic MRSA cultures were treated with vehicle (DMSO 0.05%), clindamycin (0.25 μg/mL), Azan-7 (100 μM), or clindamycin plus Azan-7. The bacterial cells were quantified by measuring OD600 nm and data are reported as % changes over the control (n = 3). ****P < 0.0001 vs. MRSA treated with DMSO 0.05%, ****P < 0.0001 vs. MRSA treated with clindamycin. (C) Alternatively, MRSA cultures were diluted and plated on LB agar for colony enumeration. Data are reported as mean ± SEM (n = 3). **P < 0.01 vs. MRSA treated with clindamycin 0.25 μg/mL).