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Progesterone suppresses N. gonorrhoeae-induced NLRP3 inflammasome activation in murine models. The mRNA levels of NLRP3 were assayed in the vaginal (A) and cervical (B) tissues on day 5 after inoculation. The mRNA levels of pro-IL-1β were assayed in the vaginal (C) and cervical (D) tissues on day 5 after inoculation. All data are representative of at least three independent experiments. **p < 0.01. Data are presented as the mean ± SD, n = 5. Ovx–, ovariectomy; P4, progesterone.
