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. 2021 Feb 4;23:1229–1242. doi: 10.1016/j.omtn.2021.01.033

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Investigation of alternative polyadenylation in LGG

(A) Percentage of distal polyadenylation site usage index (PDUI) value of immune-related genes of each patient in TCGA dataset. Patients were classified into three clusters based on the distance of the PDUI value. (B) Kaplan-Meier analysis of three clusters in overall survival. (C) Correlation between PDUI value and RNA expression of immune-related genes. (D) Multivariate Cox analysis identified seven immune-related genes with poor collinearity. (E) Association between immune-related genes and gene mutations. (F and G) Survival analysis of alternations of immune-related genes in overall survival (F) and disease-free survival (G).