Table 1.
Univariate analysis of biomarkers analyzed using the Bio-Rad’s premixed Bio-Plex Pro Human Cytokine 27-plex Assay and 21-plex Assay.
| Biomarker | Median (pg/ml) | IQR (pg/mL) | HR* | 95% CI* | p value* | FDR-corrected p value* |
|---|---|---|---|---|---|---|
| IL-1b | 7.66 | 6.11–9.55 | 1.16 | 0.441–3.04 | 0.768 | 0.959 |
| IL-1ra | 84.4 | 62.3–119 | 1.13 | 0.555–2.29 | 0.740 | 0.959 |
| IL-2 | 0.86 | 0.770–5.62 | 1.08 | 0.847–1.37 | 0.538 | 0.959 |
| IL-4 | 17.7 | 15.2–22.2 | 0.750 | 0.285–1.97 | 0.560 | 0.959 |
| IL-5 | 8.31 | 3.54–17.9 | 0.990 | 0.726–1.35 | 0.947 | 0.966 |
| IL-6 | 13.8 | 8.81–23.7 | 1.64 | 1.082–2.50 | 0.020 | 0.250 |
| IL-7 | 21.8 | 13.1–29.7 | 0.917 | 0.560–1.50 | 0.730 | 0.959 |
| IL-8 | 43.2 | 32.8–61.4 | 4.88 | 2.00–11.92 | < 0.001 | 0.024 |
| IL-9 | 320 | 265–389 | 0.978 | 0.432–2.22 | 0.957 | 0.966 |
| IL-10 | 12.0 | 6.94–18.5 | 1.17 | 0.782–1.74 | 0.451 | 0.959 |
| IL-12p70 | 42.2 | 30.2–62.3 | 1.41 | 0.812–2.44 | 0.223 | 0.666 |
| IL-13 | 5.32 | 3.46–8.99 | 1.17 | 0.719–1.91 | 0.521 | 0.959 |
| IL-15 | 0.84 | 0.662–1.38 | 1.06 | 0.821–1.37 | 0.659 | 0.959 |
| IL-17 | 141 | 107–180 | 1.62 | 0.541–4.86 | 0.389 | 0.959 |
| Eotaxin | 165 | 126–222 | 0.875 | 0.448–1.71 | 0.696 | 0.959 |
| FGF basic | 164 | 122–204 | 0.883 | 0.306–2.55 | 0.819 | 0.959 |
| G-CSF | 128 | 96.8–171 | 1.03 | 0.408–2.62 | 0.945 | 0.966 |
| GM-CSF | 2.64 | 0.978–23.4 | 1.03 | 0.831–1.28 | 0.770 | 0.959 |
| IFN-g | 88.4 | 70.0–111 | 1.07 | 0.449–2.57 | 0.874 | 0.966 |
| IP-10 | 1690 | 1120–2440 | 1.02 | 0.549–1.89 | 0.955 | 0.966 |
| MCP-1 | 28.6 | 20.6–40.4 | 1.07 | 0.667–1.70 | 0.789 | 0.959 |
| MIP-1a | 6.10 | 4.85–7.81 | 1.29 | 0.437–3.83 | 0.642 | 0.959 |
| PDGF-bb | 6150 | 4430–8150 | 0.928 | 0.507–1.70 | 0.809 | 0.959 |
| MIP-1b | 274 | 176–398 | 0.806 | 0.441–1.47 | 0.482 | 0.959 |
| RANTES | 43,700 | 5980–90,000 | 0.930 | 0.707–1.22 | 0.608 | 0.959 |
| TNF alpha | 203 | 171–241 | 1.04 | 0.425–2.56 | 0.927 | 0.966 |
| VEGF | 94.8 | 60.2–139 | 1.18 | 0.597–2.35 | 0.628 | 0.959 |
| IL-1a | 0.417 | 0.394–1.44 | 1.11 | 0.698–1.75 | 0.668 | 0.959 |
| IL-2Ra | 130 | 93.70–184 | 2.35 | 1.09–5.09 | 0.030 | 0.271 |
| IL-3 | 46.5 | 15.4–92.2 | 1.18 | 0.892–1.56 | 0.246 | 0.666 |
| IL12p40 | 4.84 | 4.46–6.74 | 0.951 | 0.725–1.25 | 0.717 | 0.959 |
| IL-16 | 116 | 76.7–172 | 1.62 | 0.866–3.04 | 0.131 | 0.662 |
| IL-18 | 92.0 | 66.3–128 | 1.69 | 0.731–3.91 | 0.219 | 0.666 |
| CTACK | 973 | 739–1240 | 2.92 | 1.09–7.86 | 0.034 | 0.271 |
| GROa | 158 | 114–225 | 1.66 | 0.769–3.57 | 0.197 | 0.666 |
| HGF | 707 | 500–958 | 1.29 | 0.599–2.76 | 0.520 | 0.959 |
| IFN-a2 | 15.4 | 3.22–31.0 | 1.23 | 0.865–1.75 | 0.248 | 0.666 |
| LIF | 8.71 | 1.92–20.8 | 1.12 | 0.808–1.55 | 0.500 | 0.959 |
| MCP-3 | 2.31 | 1.72–8.33 | 0.994 | 0.757–1.31 | 0.966 | 0.966 |
| MCSF | 17.6 | 12.1–27.1 | 1.52 | 0.856–2.71 | 0.152 | 0.663 |
| MIF | 1380 | 795–2190 | 1.97 | 1.11–3.50 | 0.021 | 0.250 |
| MIG | 259 | 165–452 | 1.75 | 0.985–3.12 | 0.056 | 0.359 |
| b-NGF | 3.05 | 1.03–6.89 | 1.27 | 0.861–1.87 | 0.229 | 0.666 |
| SCF | 157 | 127–198 | 1.73 | 0.679–4.42 | 0.250 | 0.666 |
| SCGF-b | 15,700 | 11,500–21,000 | 1.15 | 0.570–2.33 | 0.693 | 0.959 |
| SDF-1a | 92.9 | 74.3–108 | 6.26 | 1.36–28.9 | 0.019 | 0.250 |
| TNF b | 6.81 | 3.91–10.3 | 1.46 | 0.885–2.43 | 0.138 | 0.662 |
| TRAIL | 141 | 97.9–208 | 0.691 | 0.470–1.02 | 0.060 | 0.359 |
IQR interquartile range, HR hazard ratio, 95% CI 95% confidence interval, FDR false discovery rate, Bolded markers have a p < 0.1
*Calculated on logarithm values of biomarker.