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. 2021 Feb 9;9:635511. doi: 10.3389/fcell.2021.635511

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Copyright © 2021 Kopf and Kiermaier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microtubule-actin crosstalk at the B cell synapse. Upper panel: in resting B cells, Arp2/3-mediated actin nucleation at the centrosome tethers the MTOC to the nucleus. Upon B cell receptor activation, Arp2/3 and F-actin are recruited to the immune synapse thus facilitating centrosome-nucleus separation and repositioning of the MTOC to the cell-cell contact side. Lower panel: proteasomal activity is required for centrosomal actin depletion and subsequent centrosome relocalization to the immune synapse (Obino et al., 2016; Ibañez-Vega et al., 2019).