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. 2021 Feb 9;8:630543. doi: 10.3389/fcvm.2021.630543

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Copyright © 2021 Bourgonje, Bourgonje, Abdulle, Kieneker, la Bastide-van Gemert, Gansevoort, Bakker, Mulder, Pasch, Saleh, Gordijn and van Goor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restricted cubic splines (RCS) showing no deviance from linear associations of serum free thiols with the risk of CV events in females from the general population. (A) Cox proportional hazards regression analysis of serum free thiols with estimated associations with the risk of cardiovascular events based on restricted cubic splines with three knots (Model 1). (B) Cox proportional hazards regression analysis of serum free thiols with estimated associations derived from the fully adjusted model (Model 4). Median of serum free thiols was taken as reference standard (5.02 μmol/g). Likelihood ratio test for non-linearity was not statistically significant (χ² = 0.14; P = 0.708). Light-blue shaded areas represent 95% confidence intervals.