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. 2021 Feb 22;11:4325. doi: 10.1038/s41598-021-83399-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of GTG and molecular karyotyping of cell lines with r(18). (a) aCGH profiles of chromosome 18 showing a terminal deletion 1.238 Mb at 18q23 and a large (13.52 Mb) deletion at 18p11.32p11 in lymphocytes (left) and fibroblasts (right) [CytoGenomics (v. 3.0.6.6) (https://www.agilent.com/en/download-agilent-cytogenomics-software)]. (b) Karyotype rates in lymphocytes and fibroblasts (left) and iPSC lines (right) at different passages. (c) aCGH profiles of chromosome 18 in 3 iPSC lines: iPSC-r(18)-1 with a stable ring structure, iPSC-r(18)-2 with signs of multiple rearrangements or chromothripsis with the absence of most genetic content, and iPSC-r(18)-3 with signs of multiple rearrangements or chromothripsis [CytoGenomics (v. 5.0.2.5) (https://www.agilent.com/en/download-agilent-cytogenomics-software)]. (d) Example of metaphase spread with two marker chromosomes in line iPSC-r(18)-2. (e) Images of chromosome 18 pairs in fibroblasts and iPSCs with r(18) and its derivatives.