Table 3.

Quadratic model and the coefficients for the vesicles size, EE and in vitro release of ITZ loaded invasomes formulation

Terms	Y1-Vesicles size (nm)			Y2-EE (%)			Y3-In vitro release (%)
	Coefficient	SE	Rangea	Coefficient	SE	Rangea	Coefficient	SE	Rangea
X1	61.35	5.43	51.19 to 71.51	13.15	1.58	9.42 to 16.89	− 5.59	1.31	(− 8.70) to (− 2.48)
X2	18.43	4.30	8.28 to 28.59	3.00	1.58	(− 0.73) to 6.74	8.43	1.31	5.32 to 11.54
X1X2	− 6.14	6.07	(− 20.50) to 8.23	2.90	2.24	(− 2.39) to 8.18	− 6.48	1.86	(− 10.88) to(− 2.09)
X21	− 21.54	4.61	(− 32.43) to (10.65)	− 7.53	1.69	(− 11.54) to (− 3.53)	− 11.39	1.41	(− 14.47) to(− 8.06)
X22	− 4.68	4.61	(− 15.57) to 6.21	− 6.73	1.69	(− 10.74) to (− 2.72)	− 3.15	1.41	(− 6.49) to0.18

X₁ Phospholipid (mg), X₂ Valencene (%), CV coefficient of variation, EE entrapment efficiency, ITZ itraconazole, SE standard error

^aThe range indicates the lower and upper value of coefficients at 95% confidence interval