Table 4.

Analysis of variance for response surface quadratic model

Terms	Y1-Vesicles size (nm)			Y2-EE (%)			Y3-In vitro release (%)
	F values	P values	Remarks	F values	P values	Remarks	F values	P values	Remarks
Quadratic model	49.10	< 0.0001	Significant	21.20	0.0004	Significant	27.60	0.0002	Significant
X1	204.03	< 0.0001		69.27	< 0.0001		18.07	0.0038
X2	18.42	0.0036		3.61	0.0992		41.10	0.0004
X1X2	1.02	0.3459		1.68	0.2359		12.16	0.0102
X21	21.87	0.0023		19.76	0.0030		65.27	< 0.0001
X22	1.03	0.3433		15.76	0.0054		4.99	0.0605
Lack of Fit	4.94	0.0783	Not significant	5.65	0.0639	Not significant	3.14	0.1487	Not significant

X₁ phospholipid (mg), X₂ valencene (%), EE entrapment efficiency