Table 1.

Details of participating centers, frequency of MT+IA and typical mode of intra-arterial administration

Center	IA	Median dose	Observational	MT+IA	AC MT in study period	%	Typical mode of intra-arterial administration
							Microcatheter injection	Localization of microcatheter	Speed of injection	Control series (time point)
University Hospital Bochum	tPA	8 (4–18) mg	01/2011–05/2019	11	1,020	1	Yes	As distal as safely possible, usually before clot	1 mL/min	One control run 10 min after final injection
University Hospital Helsinki	tPA	3 (2–5) mg	01/2016–10/2019	31	770	4.0	Yes	As distal as safely possible, usually before clot	Small boluses of 1 mg/5 min	Control run after each 1 mg bolus (usually at 5 min after injection)
University Hospital Bern	UK	250.000 (250.000–500.000) IU	01/2010–12/2018	117	1,195	9.8	Yes	As distal as safely possible, usually before clot	Full dose over 30 min using a syringe infusion pump.	Immediately after infusion is finished, no additional control run
University Hospital Strasbourg	tPA	11 (10–15) mg	01/2018–01/2019	28	142	19.7	Yes	As distal as safely possible	5 mL/min injection by hand using a 5 mL syringe	Immediately after infusion is finished, no additional control run
University Hospital Essen	tPA	10 (5–10) mg	01/2015–09/2019	13	380	3.4	Yes	Proximal infusion (M1) in case of M3/M4	5 mL/min injection by hand using a 5 mL syringe	Immediately after infusion is finished, no additional control run
								Otherwise as distal as possible
University Hospital Münster	tPA	10 (7–18) mg	01/2015–12/2016	4	216	1.9	Yes	As distal as safely possible	5 mL/min injection by hand using a 5 mL syringe	Immediately after infusion is finished, no additional control run
University Hospital Köln	tPA	7 (5–10) mg	01/2018–10/2019	76	270	28.1	n=31 (administration via microcatheter)	Microcatheter: As distal as possible usually before clot	1 mL/min injection by hand using a 10 mL syringe	Immediately after infusion is finished, no additional control run
							n=45 (administration via distal access catheter)	Distal access: proximal infusion (usually M1 for e.g., residual M3 occlusion)
University Hospital Göttingen	tPA	11 (9–18) mg	01/2016–08/2019	13	577	2.3	Yes	As distal as safely possible (usually just before clot)	0.5–1 mL/min injection by hand using multiple 1 mL syringes	Immediately after infusion is finished, no additional control run
University Hospital Hamburg	tPA	10 (10–18) mg	01/2015–01/2018	5	762	0.7	Yes	As distal as safely possible (usually just before clot)	1 mL/min injection by hand using multiple 1 mL syringes	Immediately after infusion is finished, no additional control run
University Hospital Rostock	tPA	18 (9–20) mg	10/2015–10/2019	13	280	4–6	Yes	Proximal Infusion (e.g., M1 for an residual M3 occlusion)	5 mL/min injection by hand using a 5 mL syringe	Immediately after infusion is finished, no additional control run
Total				311	5,612	5.5

M1, M3, M4, first, third and fourth segment of the middle cerebral artery, respectively.

MT, mechanical thrombectomy; IA, intra-arterial; IQR, interquartile range; AC, anterior circulation; tPA, tissue plasminogen activator; UK, urokinase.