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. 2021 Feb 9;9:636913. doi: 10.3389/fcell.2021.636913

FIGURE 2.

FIGURE 2

circRNA-protein interactions. (A) circRNAs block proteins from interacting with DNAs, RNAs or other proteins, thereby compromising their original functions. (B) circRNAs recruit transcription factors, chromatin remodelers, and DNA or histone modifying enzymes to the promoters, altering transcription either positively or negatively. (C) circRNAs strengthen interactions between proteins through direct binding to both of them or just one of them; or dissociate interactions between proteins originally combined together by direct binding to both of them. (D) circRNAs transport proteins between nucleus and cytoplasm, and to the mitochondria or membrane.