TABLE 2.
Dysregulated onco-circRNAs in lung cancer.
| circRNA | Function | Mechanism | References |
| circFECR1 | Metastasis of SCLC | miR584-3p/ROCK1 | Li L. et al., 2019 |
| circSTXBP5L | Carcinogenesis of SCLC | miR-224-3p and miR-512-3p/Akts, NFκB, and Pik3ca | Zhang et al., 2020 |
| circ_100876 | Prognosis values | ? | Yao et al., 2017 |
| circCCDC66 | EMT and drug resistance of lung adenocarcinoma | ? | Joseph et al., 2018 |
| circF-circEA-2a | Invasion and migration of NSCLC | ? | Tan et al., 2018 |
| circRNA_102231 | Proliferation, invasion, and migration of lung cancer | ? | Zong et al., 2018 |
| hsa_circRNA_103809 | Proliferation and invasion of lung cancer | miR-4302/ZNF121/MYC | Liu W. et al., 2018 |
| circHIPK3 | Cell survival and proliferation of lung cancer | miR-124/SphK1, STAT3, and CDK4 | Yu et al., 2018 |
| Autophagy of lung cancer | miR124-3p/STAT3/PRKAA | Chen et al., 2020 | |
| EMT and aggressiveness of NSCLC | miR-149/FOXM1 | Lu et al., 2020 | |
| circPVT1 | Proliferation, invasion, and metastasis of NSCLC | miR-125b/E2F2 | Li X. et al., 2018 |
| NSCLC progression | miR-497/Bcl-2 | Qin et al., 2019 | |
| circMAN2B2 | Proliferation and invasion of lung cancer | miR-1275/FOXK1 | Ma et al., 2018 |
| circ_0067934 | Tumorigenesis, EMT, and metastasis of NSCLC | ? | Wang and Li, 2018 |
| hsa_circ_0020123 | Proliferation, invasion, and migration of NSCLC | miR-144/ZEB1 and EZH2 | Qu et al., 2018 |
| Growth, invasion, migration, and apoptosis of NSCLC | miR-488e3p/ADAM9 | Wan et al., 2019 | |
| circFADS2 | Proliferation and invasion of lung cancer | miR-498/FOXO1/KLF6 | Zhao et al., 2018 |
| circ_0016760 | Progression of NSCLC | miR-1287/GAGE1 | Li Y. et al., 2018 |
| circPRKCI | Proliferation and tumorigenesis of lung adenocarcinoma | miR-545 and miR-589/E2F7 | Qiu et al., 2018 |
| circCMPK1 | Cell proliferation of NSCLC | miR-302e/cyclin D1 | Cui et al., 2020 |
| circFGFR1 | Proliferation, migration, invasion, and immune evasion abilities of NSCLC | miR-381-3p/CXCR4 | Zhang P. et al., 2019 |
| circP4HB | EMT and metastasis of NSCLC | miR-133a-5p/vimentin | Wang et al., 2019f |
| hsa_circ_000984 | Proliferation and metastasis of NSCLC | Wnt/β-catenin signaling | Li X. et al., 2019 |
| circ_0003645 | NSCLC progression | miR-1179/TMEM14A | An et al., 2019 |
| circZFR | NSCLC progression | miR-101-3p/CUL4B | Zhang H. et al., 2019 |
| hsa_circ_0023404 | Proliferation, invasion, and migration of NSCLC | miR-217/ZEB1 | Liu C. et al., 2019 |
| F-circSR1 and 2 | Migration and invasion of NSCLC | ? | Wu et al., 2019 |
| circPRMT5 | NSCLC progression | miR-377, miR-382, and miR-498/EZH2 | Wang et al., 2019h |
| circPIP5K1A | Proliferation and metastasis of NSCLC | miR-600/HIF-1α | Chi et al., 2019 |
| circATXN7 | Proliferation and invasion abilities of NSCLC | ? | Huang Q. et al., 2019 |
| circFGFR3 | Proliferation and invasion of NSCLC | miR-22-3p/Gal-1, p-AKT and p-ERK1/2 | Qiu et al., 2019 |
| circ_0043278 | Proliferation, invasion and migration of NSCLC | miR-520f/ROCK1, CDKN1B and AKT3 | Cui et al., 2019 |
| circRAD23B | Progression of NSCLC | miR-593e3p/CCND2 and miR-653e5p/TIAM1 | Han et al., 2019 |
| circNT5E | Cell growth, proliferation, and migration of NSCLC | miR-134 | Dong et al., 2020 |
| hsa_circ_0013958 | Proliferation, invasion, and apoptosis of lung adenocarcinoma | miR-134/cyclin D1 | Zhu et al., 2017 |
| circ_0000376 | Glycolysis, cell viability, invasion and migration of NSCLC | miR-1182/NOVA2 | Li Y. et al., 2020 |
| hsa_circ_0000064 | Proliferation, apoptosis, and metastasis of lung cancer | Cell cycle regulators (p21WAF1, cyclin D1, and CDK6) and apoptotic factors (caspase-3, caspase-9, and bax) | Luo et al., 2017 |
| hsa_circ_0007385 | NSCLC progression | miR-181/Bcl-2 and CDK1 | Jiang et al., 2018 |
| circBANP | Proliferation, invasion, migration, and apoptosis of lung cancer | miR-503/LARP1 | Han et al., 2018 |
| circVANGL1 | Proliferation, migration, invasion, and apoptosis of NSCLC | miR-195/Bcl-2 and Bax | Wang et al., 2019d |
| circFOXM1 | Proliferation, invasion, migration, and apoptosis of NSCLC | miR-1304-5p/PPDPF and MACC1 | Liu G. et al., 2019 |
| circ_0026134 | Proliferation, metastasis, and apoptosis of NSCLC | miR-1287/PIK3R3 and miR-1256/TCTN1 | Chang et al., 2019 |
| circRNA 100146 | Proliferation, invasion, and apoptosis of NSCLC | miR-361-3p and miR-615-5p/NFAT5, COL1A1, TRAF3, and MEF2C | Chen L. et al., 2019 |
| circCDR1 | Cell viability, migration, invasion, and apoptosis of NSCLC | miR-219a-5p/SOX5 | Li Y. et al., 2020 |
| circ-ENO1 | Glycolysis, proliferation, apoptosis, migration and EMT of lung adenocarcinoma | miR-22-3p/ENO1 | Zhou J. et al., 2019 |
| circ-CPA4 | Cell growth, mobility, stemness, drug resistance, and CD8+ T cell inactivation in the tumor immune microenvironment of NSCLC | let-7/PD-L1 | Hong et al., 2020 |