TABLE 3.

Dysregulated tumor-suppressive circRNAs in lung cancer.

circRNA	Function	Mechanism	References
circESRP1	EMT and drug sensitivity of SCLC	miR-93-5p/Smad7/p21(CDKN1A)/TGF-β	Huang W. et al., 2019
circITCH	proliferation of NSCLC	miR-7 and miR-214/T-cell factor, β-catenin, c-Myc, and cyclin D1	Wan et al., 2016
circ_0001649	growth and metastasis of NSCLC	miR-331-3p and miR-338-5p	Liu T. et al., 2018
circPTK2	EMT and metastasis of NSCLC	miR-429 and miR-200b-3p/TIF1γ/TGF-β	Wang et al., 2018
circFOXO3	Proliferation, invasion, and migration of NSCLC	miR-155/FOXO3	Zhang et al., 2018c
hsa_circ_100395	Proliferation, invasion, and migration of lung cancer	miR-1228/TCF21	Chen D. et al., 2018
hsa_circ_0033155	Proliferation and migration of NSCLC	PTEN	Gu et al., 2019
circSMARCA5	Proliferation and chemo-sensitivity of NSCLC	miR-19b-3p/HOXA9	Wang et al., 2019g; Tong, 2020
hsa_circ_0007059	Proliferation and EMT of lung cancer	miR-378/Wnt/β-catenin and ERK1/2	Gao et al., 2019
circARHGAP10	NSCLC progression	miR-150-5p/GLUT1	Jin et al., 2019
circPTPRA	EMT and metastasis of NSCLC	miR-96-5p/RASSF8	Wei et al., 2019
has_circ_0043256	Proliferation and apoptosis of NSCLC	miR-1252/ITCH/Wnt/β-catenin	Tian et al., 2017
circNOL10	Proliferation, apoptosis, and cell cycle progression of lung cancer	SCLM1/the HN polypeptide family	Nan et al., 2018