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. 2021 Feb 9;12:614483. doi: 10.3389/fphys.2021.614483

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Copyright © 2021 Fenner, Gatta, Sattler, Kuiper, Hesselkilde, Adler, Smerup, Schotten, Sørensen, Diness, Jespersen, Verheule, Van Hunnik and Buhl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental set-up and timeline in relation to the preceding study (Fenner et al., 2020). The preceding study was conducted using an equine model of tachypacing-induced persistent AF to investigate the effect of selective I_KACh inhibition by XAF-1407. The study was based on serial attempts of pharmacologically cardioverting AF over the course of 1 month. The present study (dashed box), investigating the inhibition of small-conductance calcium-activated potassium current (I_K,Ca) in persistent AF in horses, succeeds Fenner et al. (2020) as illustrated above. The time-gap between both studies accounts for 11 ± 3 days, to ensure complete drug wash-out. The data acquired from the above illustrated experimental set-up, which is presented in this study, is marked in bold. Time points referred to throughout the main text and in Figures 2–7 are defined above (T_{–5 to 30}). Source and acquisition time points of AFCL data presented in Figure 2 are marked in red. AF, atrial fibrillation; AFCL, atrial fibrillation cycle length; RA: right atrium.